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RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle

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Pharmacologically, sodium-glucose cotransporter 2 inhibitors, such as cagliflozin, have been shown to alleviate adipose tissue dysfunction and extend longevity in prematurely aged mice ( Scutellaria baicalensis , and compound herbal formulations, including Er Zhi Wan, have been demonstrated to improve metabolic disorders by regulating metabolite levels and exerting multi-target effects on the metabolic network, ultimately contributing to the slowing of skin aging (Yun et al., 2022)

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