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L-carnitine is a naturally occurring amino acid that is synthesized mainly in the liver and kidneys and is needed for transporting long-chain fatty acids into mitochondria, where they are further broken down for beta-oxidation to release energy [5]
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Although these methods have proven clinical efficacy, they fail to directly target the central pathophysiologic mechanisms at play in heart failure
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
