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25 A Japanese study also showed that simeprevir administered QD with peg-interferon-alpha-2a and ribavirin in treatment-nave patients infected with HCV genotype 1, aged 2070 years, for 24 weeks resulted in 7792% SVR (versus 46% in placebo with peg-interferon-alpha-2a and ribavirin-treated group)

J Biol Chem 286: 1254212553, 2011

As is the case with many stress-related disorders, such as posttraumatic stress disorder, the long-standing epigenetic adaptations to extremes become dysfunctional when the organism returns to a more congenial environment