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DAMPs can trigger the production of inflammatory factors by activating PRRs, which can further damage melanocytes, leading to apoptosis and loss of function of melanocytes (68)

Katz DF, Berger SA

p66Shc, with its gene Shc1, is overexpressed in salt-sensitive hypertension rats and is involved in impaired myogenic responsiveness of renal preglomerular arterioles
