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However, a study indicated that estrogen downregulates clusterin gene expression in the rat endometrium (76), which appears to contradict the anti-inflammatory effects of estrogen
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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Sikiric P, Seiwerth S, Brcic L, Blagaic AB, Zoricic I, Sever M, Klicek R, Radic B, Keller N, Sipos K, et al

As per the McMaster Genomics Facility protocol, samples not yielding a PCR product for the 16S rRNA gene were not sent for sequencing

Based on these findings, multiple drugs have been used to intervene in CIPN, and their effects have been evaluated over the past several decades
