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These NAD + -dependent deacetylases regulate mitochondrial biogenesis through transcriptional players such as the peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), as well as pathways involved in DNA repair and redox balance [253, 254]

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B.TrivediA.PfankuchT.RaberJ.WendlandM.et al (2009)

Long-term moderate-intensity exercise induces metabolic rewiring in macrophages, enhancing mitochondrial function and shifting macrophage responses toward a more anti-inflammatory state by modulating biosynthetic and bioenergetic processes (32)

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