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WADA only regulates athletes for IV infusions that exceed 100mL within 12 hours during governed competition with the use of a Therapeutic Use Exemption

In addition, tumor heterogeneity extends beyond therapy resistance

This is convenient because the volume per unit time is a constant, whereas for drugs that are eliminated from the body by a zero-order elimination process, expressing the rate of drug elimination as mass per unit time is convenient because the clearance rate is constant and does not depend on the drug plasma concentration

& Dominguez-Gutierrez, P

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