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Although BHB had no direct effect on NMDA-evoked neurotransmitters, BHB was found to increase neurotransmitter release upon stimulation with the KATP channel blocker, glibenclamide, indicating the involvement of K ATP channels in the effects exhibited by BHB [198]
It may be connected to an enhancement of mitochondrial energy metabolism and a decrease in mitochondrial membrane permeability during the initial phase following injury
In a combined protocol, even slower titration makes theoretical sense to monitor for interactions
A study evaluated the effects of trans -dehydrocrotonin (t-DCTN), a diterpene from Croton cajucara Benth
Mitsumoto et al., 2008) (Figure 1)
