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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 267.Wang T., Xu Z., Lu Y., Shi J., Liu W., Zhang C., Jiang Z., Qi B., Bai L

View Abstract RAC reviews serious adverse event associated with AAV therapy trial