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An earlier study revealed that rotenone upregulates the proapoptotic markers Bax, p53 and caspase-3 and downregulates anti-apoptotic markers in the human liver [113]

Consistent daily use is recommended for best results

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Lactate dehydrogenase (LDH) release and ATP levels confirmed these protective effects, showing a reduction in LDH release from 212.29% to 122.98% and restoring mitochondrial membrane potential to 94.62% at 50 M of the puerarin-loaded PLGA nanoparticles
