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37 Senescent fibroblasts promote degradation of the extracellular matrix (ECM) by secreting matrix metalloproteinase-1 (MMP1) and other proinflammatory factors, 38 ultimately leading to thinning of the epidermis and decreased barrier function, 39 while the selective removal of senescent cells leads to normalization of the ECM and a reduction in inflammation

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Third-party peptide testing through independent labs should confirm identity, purity (minimum 98% for neurological applications), and the absence of endotoxins, heavy metals, and residual solvents

doi: 10.1016/0893-133X(95)00079-S