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In a smaller, double-blind, placebo-controlled trial in 256 older adults, ages 60-75 years, co-supplementation with 300 mg/day of all - rac --tocopherol and 400 mg/day of vitamin C for one year reduced a biomarker of oxidative stress (malondialdehyde) but had no effect on cognitive performance measured by the Mini Mental State Examination (MMSE) scoring system (109)

RAS inhibition in pancreatic cancer A long-standing moon-shot in pancreatic cancer has been a RAS inhibitor, to target the mutations that drive ~90% of cases

Ho and Nation, 2018