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As oligodendrocytes are the primary iron-containing cells in the brain and play a crucial role in maintaining iron homeostasis for myelin synthesis through the expression of transferrin and ferritin [182], their degeneration can release excess iron into the local environment, potentially exacerbating oxidative damage and ferroptosis

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There is also evidence for HIF-1 stabilization by cigarette smoke in pulmonary tissue, but not in endothelial tissue, where smoke seems to decrease HIF-1 expression 17,95

Neuropathy was reported on days when OIPN patients experienced sensitive peripheral neuropathy or cold-associated paresthesia