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Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors

doi: 10.7554/eLife.61798

Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only

The studies opened new insights, not least the equal importance of IGF-I and IGF-II in fetal growth, reducing birth weight by about 60% in both Igf1 knock-out ( Igf1 ko) and Igf2 ko animals and demonstrating that the previous perceived concept that there was a fetal (IGF-II) and a postnatal (IGF-I) form of IGF was incorrect

They also increase infection risk