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As indicated above the elevated NADH resulting from the metabolism of ethanol results in the impairment of hepatic gluconeogenesis from lactate, alanine (and other amino acids), and glycerol

Acknowledgements We thank Abdel Belaidi for comments on the manuscript, Nicholas Stroustrup and Walter Fontana for providing their raw data to enable validation of our temporal scaling analysis and acknowledge the Australian Synchrotron

Boelsterli et al., Figure 1 Drug-induced damage A rising number of cases of acute liver failures are reported every year in the United States, and drugs contribute majority of them, e -induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells