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PMID: 30098070 51

In severe cases, it can affect mental health, resulting in depression or even cognitive decline

The researchers commented, " Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4, and the scores were significantly lower in Group 4 than in Groups 2 and 3

[DOI: 10.1177/0379572115585772] [DOI] [PubMed] [Google Scholar] Castelli 2011 Castelli MC, Friedman K, Sherry J, Brazzillo K, Genoble L, Bhargava P, et al

Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression