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These factors have been comprehensively reviewed in earlier reports (Bitter et al., 2011

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Patients showed elevated insulin levels and a decrease in systolic blood pressure

AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB