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Cochrane Database Syst Rev 2018

Excess folate in the presence of low Vitamin B12 levels can lead to problems however the B12 deficiency is effectively masked by the action of folate which will apparently resolve the megaloblastic anaemia caused by deficiency of either vitamin, but will not resolve the effects of B12 lack

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Vitamin B12 has a good safety profile, but some important considerations include rare hypersensitivity reactions (including anaphylaxis) with injections, potential hypokalaemia during early treatment of severe deficiency, and possible cutaneous reactions