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In the DCOG ALL-10 and ALL-11 trials, patients with very high-risk features received an intensified treatment regimen that included three high-dose chemotherapy blocks after consolidation

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Further investigation into copper binding to and its inhibition of GABA A receptors has revealed that in contrast to zinc, containing GABA A Rs are sensitive to inhibition by copper and that those comprised of 1 3 2 subunits are more sensitive to block by this metal than those containing 6 3 2 (Kim & Macdonald, 2003)