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This was shown to be due to increased H 2 O 2 -mediated aryl hydrocarbon receptor nuclear translocation and A20 inhibition, providing a positive feedback loop for increased ROS and pro-inflammatory gene expression (Nakajima and Kitamura, 2013

Alternatively, pyruvate can be converted into acetyl-coenzyme A (acetyl-CoA) by the pyruvate dehydrogenase complex, serving as a precursor for the synthesis of amino acids, phospholipids, ketone bodies, and other substrates (Shi and Tu, 2015)

2013), and mitochondrial targeted antioxidants can protect against muscle atrophy (Min et al

Furthermore, unbalanced estrogen stimulation can lead to endometrial hyperplasia and endometrial cancer (230)

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