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The computer-based analysis of pCLE features, including vessel tortuosity, crypt morphology and fluorescein leakage, enables objective and quantitative assessment of structural and functional damage to the barrier.46 Furthermore, the sophisticated pCLE-based barrier assessment has the potential to clarify drug transport across the intestinal barrier and aid clinical translation in drug development, in particular biologics in IBD and molecularly targeted therapies in CRC.55 Ex vivo computer-aided pCLE molecular imaging with fluorescein-conjugated biologics (infliximab and vedolizumab), studying pretreatment binding to biological agents, was correlated with an augmented probability of treatment efficacy.46 Similarly, an ex vivo convolution neural network-based approach has been developed for analysing label-free leucocyte trafficking dynamics across vascular barriers.56 Moreover, several studies integrating AI and computer-aided diagnosis with virtual chromoendoscopy and ultra-high magnification endoscopy have demonstrated that AI-based analysis of microvascular architecture on colorectal mucosa can predict histological inflammatory activity, as well as the risk of subsequent relapse in UC patients.5759 Fusing AI and advanced endoscopic technology may open in vivo vascular barrier assessment

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Written by Elizabeth Tito, BSc Genetics, MPH Elizabeth is a science and medical writer with a background in Genetics and Public Health

Histoire [modifier | modifier le code] Les recherches sur cette vitamine sont issues de la description au dbut du XIX e sicle d'une anmie mortelle, l'anmie pernicieuse, par diffrents auteurs dont Thomas Addison ou Anton Biermer [4] , [5] , [6]