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1,4 Hyperglycemia, dyslipidemia, and insulin resistance activate various metabolic pathways, resulting in oxidative stress, mitochondrial dysfunction, inflammation, and microvascular damage, culminating in neuronal injury, Schwann cell damage, and myelin sheath degeneration

10.1016/j.bioactmat.2022.07.024 276 XiaQ.ZhaoY.DongH.MaoQ.ZhuL.XiaJ.et al (2024)

TB-500 supports tissue repair by promoting cell movement, reducing inflammation, and improving blood vessel formation within damaged tissue

Further, immune tolerance induction (ITI) protocols to mitigate ADAs are protracted (can last months to years), highly immunosuppressive (as in the case of Pompe disease) [14], and are not always effective, with little recourse available for patients who fail ITI [15]
