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2019 Jun;24:101171

While the LIP exists throughout the cytosol, the mitochondrial compartment is uniquely vulnerable in FRDA due to the simultaneous pathological iron overloading and localized H 2 O 2 overproduction from impaired respiratory complexes [53,54]

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.de La Torre R., Farr M

As a result, the agent releases to the extracellular space

With the advancing proteomic, lipidomic, and genomic technologies, effectiveness of hybrid LNCs could be increased to achieve scalability and create affordable, effective dosage forms (98)