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In this test, animals are placed in a pool of water from which they cannot escape or touch the bottom, typically exhibiting a state referred to as behavioral despair. The effectiveness of antidepressants is generally assessed in the FST by reducing the time spent in passive floating and increasing the time struggling and swimming, thus reflecting the potential antidepressant activity of the compounds

These experimental results provide evidence supporting our hypothesis that SREBP1 serves as a central target in formononetin-induced ferroptosis

60 min prior to oral glucose) significantly improves the glucose tolerance capacity by decreasing the AUC 0120min of 19.3% compared with the vehicle group in ob/ob mice [3]

Furthermore, GGCT formed a tightly regulated positive feedback loop together with REST and miR-34a-5p