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NOX1 and NOX2 generate superoxide, and NOX4 generates hydrogen peroxide [411]

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3.3 Innate immune pathways involved in melanoma (B16-F10) treatment with BCG In order to determine the role of innate immune pathways related to BCG immunotherapy in vivo , we compared our model in WT ( Figure 1A ) with different KO mice (TLR2 -/- , TLR3 -/- , TLR4 -/- , TLR7 -/- , TLR3/7/9 -/- , Caspase-1/11 -/- , Caspase-11 -/- , IL-1R -/- , cGAS -/- , STING -/- and IFNAR -/- )

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In addition, BALF from WT mice contained higher levels of double-stranded DNA (dsDNA) compared to that of XKR8 KO mice (Fig