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The significance of muscle is even more evident in insulin resistance state: in high fat diet (HFD) fed mice or db/db mice, although BCAA oxidation is decreased by up to 60% in tissues like liver and adipose tissue, BCAA oxidation in skeletal muscle either remained unchanged or increased 50% (Neinast et al., 2018)

Since it was determined that NO has a vital role in the control of blood flow, scientists have speculated on the effects increased levels would have on cardiovascular functioning in particular and exercise performances in general

Studies looking at methylcobalamin alone have also been encouraging

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