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Causes of Vitamin B12 Deficiency Inadequate dietary intake Malabsorption disorders Insufficient stomach acid Surgical procedures Autoimmune conditions Medications Age-related factors Inadequate dietary intake Vitamin B12 is found only in animal products such as eggs, meat, fish, and dairy products, but vegans and vegetarians do not consume animal products, therefore it is easy to develop vitamin B12 deficiency

The inserted amino acid in the QueD2 Cx 4 HGH motif displaces the Cys nucleophile far from the catalytic site, while shifting the metal coordinating HGH motif (His28 and His30 in Ab QueD2) further into the 2 strand relative to Ec QueD

68 Detailed analysis suggests a multipronged effect of the changes in intestinal claudin-1 expression, including mucosal barrier properties (mucin-2 expression) and epithelial homeostasis

More importantly, the mechanistic rationale fits acute repair better than it fits osteoarthritis

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