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Its effects are peripheral, working inside adipocytes and hepatocytes to restore NAD+-dependent metabolic flexibility

The subcutaneous layer may be less uniform, with areas of tissue thinning alternating with areas of normal thickness

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The remaining 25 articles were included in the qualitative synthesis, and 16 in the quantitative synthesis (Figure 1)

The reformulated version aims to match orforglipron's convenience while potentially achieving higher peak efficacy through pulsatile dosing