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Essentially, two groups can be distinguished: (i) molecules containing GSH or GSH-like moiety and (ii) molecules whose enzymatic activation occurs through a GSH-conjugate intermediate 109

CMSP RL, Yothers G, Jacobs SA, Sanoff HK, Cohen DJ, Guthrie KA, Henry NL, Ganz PA, Kopetz S , Lucas PC, Blanke CD, Wolmark N, Hochster HS, George TJ, Overman MJ

Devising efficient synthesis of -conotoxin and RANTES with two disulfide bonds As a model system we chose the well characterized and studied -conotoxin SI peptide, composed of 13 AAs and having two disulfide bonds between Cys (2&7) and Cys (3&13) that induce the 3 10 helix shape 15

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