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Animal Models of Parkinsons Disease

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These ranges are far wider than what would generally be considered ideal for a central nervous system (CNS) active drug candidate [17]

They have a dual role in biological systems, both beneficial than harmful depending on their nature and concentration as well as location and length of exposure (1)

impermeants that can be included in the physiologically acceptable solutions provided herein include, without limitation, lactobionate, raff nose, hydroxyethyl starch (HES), gluconate, saccharate, and sorbitol