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In addition to targeting fully complementary mRNAs, siRNAs can bind to multiple miRNA-like sites in transcripts' 3 UTRs via partial seed sequence complementarity

doi:10.2147/tcrm.s3552

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These combinatorial strategies aim to create a permissive TME that supports robust T-cell infiltration, thereby overcoming a foundational bottleneck to effective antitumor immunity

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