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Description
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The human skin is a complete steroidogenic organ, as intracrine estrogen biosynthesis occurs either from precursors of adrenal origin (dehydroepiandrosterone sulfate [DHEA-S] and DHEA) or through the conversion of cholesterol to pregnenolone and its subsequent transformation to biologically active estrogen in skin cells (Labrie et al., 2000
[DOI] [PubMed] [Google Scholar] 88.Cai J., Chen Y., Seth S., Furukawa S., Compans R., Jones D.P

Disruption and recovery of testicular function during and after androgen abuse: the HAARLEM study

It drastically slows their metabolic processes and their ability to reproduce
