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GPR146 regulates adipogenesis through Gq-mediated activation of PKC signaling pathway in both human and mouse preadipocytes To elucidate the molecular mechanism by which GPR146 regulates adipogenesis, we performed phosphoproteomics profiling of SGBS cells with or without GPR146 knockdown following three days of differentiation
Finally, as both increasing age and germ-free conditions have been associated with a decline Drosophila antioxidant responses 22,23 , we defined the requirement of the antioxidant response system in our model and find, in agreement with vertebrate studies, that genetic and pharmacologic manipulations of antioxidant response pathways results in altered sensitivity to APAP toxicity 24,25

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