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TORC1 blocks the initiation of autophagy through the phosphorylation (inactivation) of Atg13, ULK, AMBRA, and Atg-14L, inhibiting the complex Atg13-ULK1 and the activity of ULK1 and vps34

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The g-Glu-CysSSCys generated by g-glutamyltranspeptidase is rapidly reduced in the cell cytosol to g-Glu-Cys and cysteine

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215 With age, the reduced pool of nave T cells may impair the ability of the immune system to detect these antigens, creating what is referred to as holes in the repertoire. This limitation could reduce the effectiveness of immunotherapies targeting neoantigens