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In contrast, overactivation of NMDAR by NMDA agonists increases the cytosolic concentrations of calcium and zinc, which significantly contributes to neural death, an effect known to be prevented by cannabinoids, mediated by activation of the CB 1 receptor, which leads HINT1 protein to counteract the toxic effects of NMDAR-mediated NO production and zinc release

In the first step of the assay, the ABTS reagent was mixed with potassium persulfate to generate free radicals

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As oxidizing agents, ROS interfere with intracellular functions, being capable of damaging various cellular elements, including cell membranes, proteins, lipids and nucleic acids, and ultimately resulting in mitochondrial dysfunction and loss of enzymatic activity (19, 20)

A tunable LDI-MS platform assisted by metal-phenolic network-coated AuNPs for sensitive and customized detection of amino acids