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It has been demonstrated that the expression of PON2 with intact lactonase activity facilitates 3OC12-HSL degradation in human airway epithelial cells and murine tracheal epithelial cells, suggesting that PON can disrupt the P

This cytokine shift, which enhances antiviral and antitumor immune responses, which are critical for the elderly to fight age-associated diseases, is linked to an increase in NK cell numbers, potentially explaining the enhanced IFN- production [212]

The anti-inflammatory action could counter COVID-related oxidative damage

doi: 10.1089/ars.2012.5149 26 RenXZouLZhangXBrancoVWangJCarvalhoCet al

Antioxidants like melatonin counter reactive oxygen species (ROS)-induced spindle defects and mitochondrial dysfunction, showing benefits in murine oocyte maturation and blastocyst development