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The experiment involved inducing acute gouty inflammation in rats using monosodium urate crystal (MUC) and acute inflammation in mice using LPS

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For the western blotting of HMGB1, frozen cortices were homogenized in 50 mM TrisHCl (pH 7.5) containing protease inhibitor cocktail and phosphatase inhibitor cocktail

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ClinicalTrials.gov TRANSCEND-T2D-1: A Study of Retatrutide (LY3437943) in Adult Participants With Type 2 Diabetes (NCT06354660)