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Description
In CLL, a higher OCR is associated with prognostically unfavorable factors such as advanced stage, unmutated IGHV status, ZAP-70 positivity, and high level of 2-microglobulin as well as development of drug resistance (17) and an increased risk of Richters transformation (38)

Wang N, Wang Z, Sun H, Shi X, Zhang Y, Liu Q

Paraffin blocks were cut into 5 and 3- m slices

Oxidative stress activates melanocytes, the cells responsible for producing melanin, and pushes them into overdrive

Notably, these analyses identified strain-specific phenotypic differences in FRC subsets, with red pulp reticular cells (RPRCs) from BALB/c mice lacking Ly6C, an identifier of RPRCs in C57BL/6 33 (Extended Data Fig
