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A combination of sorafenib plus TMZ prevented autophagy induction by sorafenib and promoted apoptosis, mainly by downregulating the expression of Raf, Hsp27, and Hsp72, increasing ER stress [207]

SandholmNColeJBNairVShengXLiuHAhlqvistEet al

The original separation membrane is formed on ER from locally synthesized lipids, then an increase in the biosynthesis of the bilayer-forming phospholipids [phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS)] occurs simultaneously with the induction of autophagy (Figure 2)

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ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors