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Excess bile, a heme byproduct, can form gallstones, block bile flow, damage the liver and bile ducts, and raise GGT and ROS levels

129 NIX can be ubiquitinated by Parkin, and ubiquitinated NIX in turn recruits NBR1 to promote mitophagy

NADPH oxidase-derived ROS: key modulators of heme-induced mitochondrial stability in human neutrophils

doi: 10.1093/jxb/ers297

You may have itching at the injection site for several reasons
