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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

Thus, we hypothesized that TBI can be attenuated by vitaminB 12 treatment through its beneficial role on axon regeneration after nerve injury

Ongoing monitoring of B12 levels should occur on a yearly basis