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Targeting the SCAN instead of effector regions doubled the efficacy of TMS treatments

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its drug, dubbed MariTide, produced about 20% weight loss, on average, over the course of a year in mid-stage trial results reported in November

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The regulation of B cell lymphoma extra-large deamidation has a critical role in the tumour-specific activity of DNA-damaging antineoplastic agents 29,30 , suggesting that deamidation might also be a functional PTM affecting the DDR