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139,140 Astroglial detrimental effects through loss or gain of functions There is mounting interest in how astrocytes that are reactive or diseased might have detrimental effects on the outcome of disorders

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Furthermore, TGRL and their lipolytic products activate platelet aggregation and clot formation by suppressing fibrinolysis and promoting the assembly of prothombinase complex, the expression of plasminogen activator inhibitor-1 and its antigen, and the endothelial expression of tissue factor (Gianturco and Bradley, 1999