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10.1002/ijc.30252 350 WasH.BarszczK.CzarneckaJ.KowalczykA.BernasT.UzarowskaE.et al (2017)
"Leber's hereditary optic neuropathy and vitamin B12 deficiency"
Taken together, unmistakable evidence has been gathered that points to a strong link between autism and mitochondrial respiratory dysfunction (summarized in Table 1)
This tight coupling is at the basis of functional brain-imaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging
Furthermore, some limitations derived of treatment resistance to targeted therapies against glutamine metabolism have been reported
