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Once it reaches the duodenum, it is released from the R proteins by the action of proteases and pancreatic bicarbonate, which cause the elimination of the initially formed complex, leaving B12 free

Nicklin P., Bergman P., Zhang B., et al., Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy, Cell 136, no

10.1038/349760a0 124 MasuokaT.IkedaR.KonishiS

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