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doi: 10.1016/j.cmet.2019.11.010 86 PabstTKortzLFiedlerGMCeglarekUIdleJRBeyogluD

292,293 This fact indicates the redundant functions of various signaling pathways that limit the therapeutic efficiency of targeting signaling molecules

When both mechanisms operate simultaneously, you create a metabolic state where the body is consuming fewer calories while simultaneously breaking down fat reserves faster
