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Lancet 396 , 413446 (2020)

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Nakamura S, Tanaka J, Imada T, Shimoda H, Tsubota K

Whereas cancer combatting effects were seen with PCSK9 inhibition in the studies discussed previously, no tumor growth reduction or survival benefit was seen with the use of anti-PCSK9 vaccination in mice bearing melanoma tumors (Momtazi-Borojeni et al., 2020), and in fact, PCSK9 siRNA protected prostate cancer cells against ionizing radiation-induced cell damage by its anti-apoptotic activity in vitro (Gan et al., 2017)

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Frye R.E., James S.J
