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2018. Therapeutic potential of NAD-boosting molecules in vivo

Empirical evidence indicates that vitrified mouse oocytes at the germinal vesicle (GV) and metaphase II (MII) stages exhibit a significant reduction in MMP, leading to mitochondrial dysfunction (47)

Oxidative Stress in Male Fertility Multiple factors can lead to an increase in oxidative stress including the physiological production of ROS, exogenous sources such as varicocele and infection, as well as environmental and lifestyle factors (Figure 1)

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GSH is utilized by glutathione peroxidase (GPX) to reduce free hydrogen peroxide and lipid hyperoxides