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Synthetic environmentally sensitive carriers such as thermosensitive carriers 28,29 , pH sensitive hydrogel 30 , magnetic response carriers (including shell/core structure 31 , core/shell structure 32 and heterofunctional structure 33 ) and multi-responsive carriers 34 , can respond to environmental stimulation factors

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10.1007/s10549-021-06304-6 35

In patients with Alzheimers disease NAD+ is depleted or has decreased, there may be neuroinflammation and patients may have cellular injury with proinflammatory cytokines

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