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While the KCH criteria had excellent specificity, it was at the expense of sensitivity, yielding a limited ability to distinguish patients who would survive with conservative medical management versus those that would die without a liver transplant

In a recent randomized controlled trial on 34 individuals with mild cognitive impairment who were administered two periods of CGA (554 mg of CGA or placebo, twice/day) for 3 months with a monthly interval, data showed improvements in cognitive functions, especially attention and executive function [269]

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10.1113/JP284767 [DOI] [PMC free article] [PubMed] [Google Scholar] Okazaki K., Stray-Gundersen J., Chapman R

Key discoveries include the impaired development and function of GABAergic interneurons, the complexity of GABA signaling disruptions (e.g., altered synthesis, transport, and receptor function), and the genetic-environmental interactions that amplify neurodevelopmental vulnerabilities